The science
Every shot starts
from a studied ingredient.
We start with ingredients that have been tested on people, use them at the doses those studies used, and tell you exactly what’s inside.
ON
Brainberry®
A US-patented aronia berry extract behind three published human studies, including a 2026 study measuring blood flow in the brain by MRI.
3 published studies
OFF
Benesomno® + magnesium
An evening formula with no melatonin, so it fits a routine rather than a one-off.
Melatonin-free
CLEAR
Cognizin® citicoline
Studied in a randomised, placebo-controlled trial of 60 healthy women aged 40 to 60. Paired with Brainberry® and saffron.
Studied in women 40–60
PRIME
SRI-81™ Shatavari
A standardised shatavari root extract, used at 300 mg a day in a 2026 clinical study of women in midlife.
300 mg studied dose
SYNC
affron® saffron
Saffron at 30 mg a day, the amount used in a double-blind study of premenstrual symptoms, with magnesium and B6.
30 mg studied dose
Study references relate to individual ingredients, not to the finished SIGNAL shots. SIGNAL is a dietary supplement for adults 18+. Speak with your healthcare professional before use if you are pregnant, breastfeeding, taking medication or have a medical condition.